122457-31-2
122457-31-2
Chemical Structure
MeIQx-d3
- CAS. Nr.: 122457-31-2
- Formula:C11H8D3N5
- Molecular Weight:216.26
IUPAC Name: 8-methyl-3-(methyl-d3)-3H-imidazo[4,5-f]quinoxalin-2-amine
InChIKey: DVCCCQNKIYNAKB-BMSJAHLVSA-N
SMILES: CC1=CN=C(C=C2)C(C(N=C3N)=C2N3C([2H])([2H])[2H])=N1
Biological Activity: MeIQx-d3 is the deuterium labeled MeIQx (HY-W355129)[1]. MeIQx is a heterocyclic amine (HAs) compound and a dietary aromatic amine, which can bind covalently to hemoglobin. MeIQx is a mutagenic compound that induces liver tumors[2].
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MeIQx-d3 | 99.0% | MeIQx-d3 is the deuterium labeled MeIQx (HY-W355129). MeIQx is a heterocyclic amine (HAs) compound and a dietary aromatic amine, which can bind covalently to hemoglobin. MeIQx is a mutagenic compound that induces liver tumors. | ||||||||||||||||||||
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MeIQx-13C | MeIQx-13C (2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline-2-13C) is the 13C-labeled MeIQx (HY-W355129). MeIQx, a dietary aromatic amine, is mutagenic compound could be isolated from present in fried beef and beef extracts. MeIQx binds covalently to hemoglobin. MeIQx induces liver tumors. | |||||||||||||||||||||
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MeIQx | 99.48% | MeIQx, a dietary aromatic amine, is mutagenic compound could be isolated from present in fried beef and beef extracts. MeIQx binds covalently to hemoglobin. MeIQx induces liver tumors. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Lynch AM, et, al. The measurement of MeIQx adducts with mouse haemoglobin in vitro and in vivo: implications for human dosimetry. Carcinogenesis. 1991 Jun;12(6):1067-72. [Content Brief]
