1227056-85-0
1227056-85-0
Chemical Structure
Ampreloxetine TFA
Synonym(s): TD-9855 TFA
- CAS No.: 1227056-85-0
- Formula:C20H19F6NO3
- Molecular Weight:435.36
InChIKey: MDURTULDKWJPAB-UHFFFAOYSA-N
SMILES: FC1=C(OCC2=CC=CC=C2C3CCNCC3)C(F)=CC(F)=C1.O=C(O)C(F)(F)F
Biological Activity: Ampreloxetine (TD-9855) TFA is a potent and orally active norepinephrine (NE) and serotonin 5-HT inhibitor. Ampreloxetine TFA has the potential for the research of neurogenic orthostatic hypotension[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Ampreloxetine TFA | 98.30% | Ampreloxetine (TD-9855) TFA is a potent and orally active norepinephrine (NE) and serotonin 5-HT inhibitor. Ampreloxetine TFA has the potential for the research of neurogenic orthostatic hypotension. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Smith JA, et al. Preclinical to clinical translation of CNS transporter occupancy of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor. Int J Neuropsychopharmacol. 2014 Dec 13;18(2):pyu027. [Content Brief]
- [2]. Kaufmann H, et al. Safety and efficacy of ampreloxetine in symptomatic neurogenic orthostatic hypotension: a phase 2 trial. Clin Auton Res. 2021 Dec;31(6):699-711. [Content Brief]
Keywords
