1227097-70-2
Chemical Structure
Dorzolamide-d5
- CAS No.: 1227097-70-2
- Formula:C10H11D5N2O4S3
- Molecular Weight:329.47
IUPAC Name: (4S,6S)-4-((ethyl-d5)amino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
InChIKey: IAVUPMFITXYVAF-YPFVYTSYSA-N
SMILES: O=S1(=O)C2=C([C@@H](NC(C([2H])([2H])[2H])([2H])[2H])C[C@@H]1C)C=C(S(N)(=O)=O)S2
Biological Activity: Dorzolamide-d5 is the deuterium labeled Dorzolamide. Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity[1][2].
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Dorzolamide-d5 | Dorzolamide-d5 is the deuterium labeled Dorzolamide. Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity. | |||||||||||||||||||||
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Dorzolamide | Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity. |
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. J Biollaz, et al. Whole-blood pharmacokinetics and metabolic effects of the topical carbonic anhydrase inhibitor dorzolamide. Eur J Clin Pharmacol. 1995;47(5):455-60. [Content Brief]
Keywords
