1234569-09-5
Chemical Structure
Lalistat 2
- CAS. Nr.: 1234569-09-5
- Formula:C13H20N4O2S
- Molecular Weight:296.39
IUPAC Name: 4-(piperidin-1-yl)-1,2,5-thiadiazol-3-yl piperidine-1-carboxylate
InChIKey: PNYYVHOTXOEBEV-UHFFFAOYSA-N
SMILES: O=C(N1CCCCC1)OC2=NSN=C2N3CCCCC3
Biological Activity: Lalistat 2 is an inhibitor of many lipases especially Lysosomal acid lipase (LAL, IC50 = 152 nM), which is a key enzyme that degrades neutral lipids at an acidic pH in lysosomes. Lalistat 2 is commonly used to investigate the cell-specific functions of LAL and LAL deficiency in vitro, as well as specifically measure LAL activity in human blood samples or cells [1][2][3].
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Lalistat 2 | 99.88% | Lalistat 2 is an inhibitor of many lipases especially Lysosomal acid lipase (LAL, IC50 = 152 nM), which is a key enzyme that degrades neutral lipids at an acidic pH in lysosomes. Lalistat 2 is commonly used to investigate the cell-specific functions of LAL and LAL deficiency in vitro, as well as specifically measure LAL activity in human blood samples or cells . | ||||||||||||||||||||
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- [1]. Bradić I, et al. Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases. Mol Metab. 2022，61，101519. [Content Brief]
- [2]. Rosenbaum AI, et al. Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J Med Chem. 2010, 53(14):5281-9. [Content Brief]
- [3]. Lukacs Z, et al. Best practice in the measurement and interpretation of lysosomal acid lipase in dried blood spots using the inhibitor Lalistat 2. Clin Chim Acta. 2017;471:201-205. [Content Brief]
Keywords
