124065-13-0
124065-13-0
Chemical Structure
DAC 5945
- CAS No.: 124065-13-0
- Formula:C19H30ClN3O
- Molecular Weight:351.91
IUPAC Name: 1-cyclohexyl-2-(4-(iminomethyl)piperazin-1-yl)-1-phenylethan-1-ol hydrochloride
InChIKey: ABECNUXOXSXJCR-UHFFFAOYSA-N
SMILES: OC(C1=CC=CC=C1)(C2CCCCC2)CN3CCN(C=N)CC3.[H]Cl
Biological Activity: DAC 5945 is a potent muscarinic antagonist in the airways than in the heart, with pKi values of 8.3 and 7.52 for M1 and M2, respectively[1][2].
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DAC 5945 | DAC 5945 is a potent muscarinic antagonist in the airways than in the heart, with pKi values of 8.3 and 7.52 for M1 and M2, respectively. | |||||||||||||||||||||
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References
- [1]. R E Howell, et al. Airway smooth muscle selectivity of the muscarinic antagonist DAC 5945 in vivo. Eur J Pharmacol. 1991 Apr 24;196(3):323-6. [Content Brief]
- [2]. H N Doods, et al. Characterization of muscarinic receptors in guinea-pig uterus. Eur J Pharmacol. 1993 Dec 7;250(2):223-30. [Content Brief]
