124387-19-5
Chemical Structure
5(6)-CFDA
Synonym(s): 5-(6)-Carboxyfluorescein diacetate; CFDA
- CAS No.: 124387-19-5
- Formula:C25H16O9
- Molecular Weight:460.39
IUPAC Name: 3',6'-diacetoxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid compound with 3',6'-diacetoxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-6-carboxylic acid (1:1)
InChIKey: ZCFZHZUTXKEHLO-UHFFFAOYSA-N
SMILES: CC(OC1=CC=C2C(OC3=C(C=CC(OC(C)=O)=C3)C24C5=CC(C(O)=O)=CC=C5C(O4)=O)=C1)=O.CC(OC6=CC=C7C(OC8=C(C=CC(OC(C)=O)=C8)C79C%10=CC=C(C(O)=O)C=C%10C(O9)=O)=C6)=O
Biological Activity: 5(6)-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes[1][2][3].
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5(6)-CFDA | 98.75% | 5(6)-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes. | ||||||||||||||||||||
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- [1]. Yang T, et al. A novel nonradioactive CFDA assay to monitor the cellular immune response in myeloid leukemia. Immunobiology. 2013 Apr;218(4):548-53. [Content Brief]
- [2]. Card SD, et al. Assessment of fluorescein-based fluorescent dyes for tracing Neotyphodium endophytes in planta. Mycologia. 2013 Jan-Feb;105(1):221-9. [Content Brief]
- [3]. Fang X, et al. Bone marrow-derived endothelial progenitor cells are involved in aneurysm repair in rabbits. J Clin Neurosci. 2012 Sep;19(9):1283-6. [Content Brief]
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