124412-57-3
124412-57-3
Chemical Structure
Dynemicin A
- CAS No.: 124412-57-3
- Formula:C30H19NO9
- Molecular Weight:537.47
InChIKey: AFMYMMXSQGUCBK-AKMKHHNQSA-N
SMILES: O=C(O)C1=C(OC)[C@H]2C#C/C=C\C#C[C@@H]3NC4=C5C(C6=C(C(O)=CC=C6O)C(C5=C(O)C=C4[C@]27O[C@@]37[C@H]1C)=O)=O
Biological Activity: Dynemicin A is a potent antitumor antibiotic. Dynemicin A is a DNA synthesis inhibitor with an IC50 of 2.2 ng/mL. Dynemicin A undergoes bioreductive epoxide ring opening and Bergman cyclization to generate a highly reactive benzenoid diradical, which specifically induces double-strand DNA cleavage. Dynemicin A can be used for research on bacterial infections, leukemia, and melanoma[1][2][3][4].
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Dynemicin A | Dynemicin A is a potent antitumor antibiotic. Dynemicin A is a DNA synthesis inhibitor with an IC50 of 2.2 ng/mL. Dynemicin A undergoes bioreductive epoxide ring opening and Bergman cyclization to generate a highly reactive benzenoid diradical, which specifically induces double-strand DNA cleavage. Dynemicin A can be used for research on bacterial infections, leukemia, and melanoma. | |||||||||||||||||||||
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References
- [1]. KONISHI M, et al. Dynemicin A, a Novel Antibiotic with the Anthraquinone and 1,5-Diyn-3-Ene Subunit. The Journal of Antibiotics, 1989, 42(9): 1449-1452.
- [2]. Pal P, et al. Dynemicin A Derivatives as Potential Cancer Chemotherapeutics by Mutasynthesis. Helvetica chimica acta. 2023 Dec;106(12):e202300123.
- [3]. Cardozo MG, et al. A model for the dynemicin-A cleavage of DNA using molecular dynamics simulation. Biopolymers. 1993 Mar;33(3):377-88.
- [4]. KAMEI H, et al. Dynemicins, New Antibiotics with the 1,5-Diyn-3-Ene and Anthraquinone Subunit. II. Antitumor Activity of Dynemicin A and Its Triacetyl Derivative. The Journal of Antibiotics, 1991, 44(12): 1306-1311.
