124622-78-2
Chemical Structure
7Et-11F-CPT
- CAS No.: 124622-78-2
- Formula:C22H19FN2O4
- Molecular Weight:394.40
InChIKey: PLQIANFTHKBYFY-QFIPXVFZSA-N
SMILES: O=C1C2=C([C@](CC)(O)C(OC2)=O)C=C3C4=NC5=CC(F)=CC=C5C(CC)=C4CN31
Biological Activity: 7Et-11F-CPT is a Topoisomerase I inhibitor and an analog of 11F-CPT (HY-190897). 7Et-11F-CPT stabilizes the TOP I‑DNA cleavage complex in a non-covalent manner, promotes TOP I-related DNA damage, and activates the ATR-CHK1 DNA damage response. 7Et-11F-CPT induces cell cycle arrest predominantly in S phase accompanied by G2/M phase, upregulates Bax, Bad, and cleaved caspase‑3, and downregulates Bcl‑2, thereby inducing tumor cell apoptosis. 7Et-11F-CPT inhibits tumor growth in the PAN02 pancreatic cancer xenograft model. 7Et-11F-CPT can be used for research on pancreatic cancer[1].
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7Et-11F-CPT | 7Et-11F-CPT is a Topoisomerase I inhibitor and an analog of 11F-CPT (HY-190897). 7Et-11F-CPT stabilizes the TOP I‑DNA cleavage complex in a non-covalent manner, promotes TOP I-related DNA damage, and activates the ATR-CHK1 DNA damage response. 7Et-11F-CPT induces cell cycle arrest predominantly in S phase accompanied by G2/M phase, upregulates Bax, Bad, and cleaved caspase‑3, and downregulates Bcl‑2, thereby inducing tumor cell apoptosis. 7Et-11F-CPT inhibits tumor growth in the PAN02 pancreatic cancer xenograft model. 7Et-11F-CPT can be used for research on pancreatic cancer. | |||||||||||||||||||||
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