1251830-50-8

Drisapersen Chemical Structure
1251830-50-8

Chemical Structure

Drisapersen

Synonym(s): Kyndrisa; GSK2402968A; PRO051

  • CAS No.: 1251830-50-8
  • Formula:C211H275N76O119P19S19
  • Molecular Weight:6977.62

SMILES: CO[C@@H]1[C@H](O)[C@@H](COP(S)(O[C@@H]2[C@@H](COP(S)(O[C@@H]3[C@@H](COP(S)(O[C@@H]4[C@@H](COP(S)(O[C@@H]5[C@@H](COP(S)(O[C@@H]6[C@@H](COP(S)(O[C@@H]7[C@@H](COP(S)(O[C@@H]8[C@@H](COP(S)(O[C@@H]9[C@@H](COP(S)(O[C@@H]%10[C@@H](COP(S)(O[C@@H]%11[C@@H](COP(S)(O[C@@H]%12[C@@H](COP(S)(O[C@@H]%13[C@@H](COP(S)(O[C@@H]%14[C@@H](COP(S)(O[C@@H]%15[C@@H](COP(S)(O[C@@H]%16[C@@H](COP(S)(O[C@@H]%17[C@@H](COP(S)(O[C@@H]%18[C@@H](COP(S)(O[C@@H]%19[C@@H](COP(S)(O[C@@H]%20[C@@H](CO)O[C@H]([C@@H]%20OC)N%21C=CC(NC%21=O)=O)=O)O[C@H]([C@@H]%19OC)N%22C=CC(N)=NC%22=O)=O)O[C@H]([C@@H]%18OC)n%23c%24ncnc(N)c%24nc%23)=O)O[C@H]([C@@H]%17OC)n%25c%26ncnc(N)c%26nc%25)=O)O[C@H]([C@@H]%16OC)n%27cnc%28c%27N=C(N)NC%28=O)=O)O[C@H]([C@@H]%15OC)n%29cnc%30c%29N=C(N)NC%30=O)=O)O[C@H]([C@@H]%14OC)n%31c%32ncnc(N)c%32nc%31)=O)O[C@H]([C@@H]%13OC)n%33c%34ncnc(N)c%34nc%33)=O)O[C@H]([C@@H]%12OC)n%35cnc%36c%35N=C(N)NC%36=O)=O)O[C@H]([C@@H]%11OC)n%37c%38ncnc(N)c%38nc%37)=O)O[C@H]([C@@H]%10OC)N%39C=CC(NC%39=O)=O)=O)O[C@H]([C@@H]9OC)n%40cnc%41c%40N=C(N)NC%41=O)=O)O[C@H]([C@@H]8OC)n%42cnc%43c%42N=C(N)NC%43=O)=O)O[C@H]([C@@H]7OC)N%44C=CC(N)=NC%44=O)=O)O[C@H]([C@@H]6OC)n%45c%46ncnc(N)c%46nc%45)=O)O[C@H]([C@@H]5OC)N%47C=CC(NC%47=O)=O)=O)O[C@H]([C@@H]4OC)N%48C=CC(NC%48=O)=O)=O)O[C@H]([C@@H]3OC)N%49C=CC(NC%49=O)=O)=O)O[C@H]([C@@H]2OC)N%50C=CC(N)=NC%50=O)=O)O[C@H]1N%51C=CC(NC%51=O)=O

Biological Activity: Drisapersen (Kyndrisa) is a 2'-O-methyl phosphorothioate RNA antisense oligonucleotide that induces exon 51 skipping. Drisapersen induces skipping of exon 51 during Dystrophin pre-mRNA splicing, allowing the synthesis of partially functional Dystrophin. Drisapersen can be used in research related to Duchenne muscular dystrophy[1][2].

Cat. No. Product Name Purity Description Pricing
HY-145724
Drisapersen 97.92% Drisapersen (Kyndrisa) is a 2'-O-methyl phosphorothioate RNA antisense oligonucleotide that induces exon 51 skipping. Drisapersen induces skipping of exon 51 during Dystrophin pre-mRNA splicing, allowing the synthesis of partially functional Dystrophin. Drisapersen can be used in research related to Duchenne muscular dystrophy.
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