1252802-38-2
Chemical Structure
NMK-TD-100
- CAS No.: 1252802-38-2
- Formula:C19H17N3O3S
- Molecular Weight:367.42
IUPAC Name: 2-(1H-indol-3-yl)-5-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiazole
InChIKey: SNKXDUJDVVZRCS-UHFFFAOYSA-N
SMILES: COC1=C(C(OC)=CC(C2=NN=C(S2)C3=CNC4=C3C=CC=C4)=C1)OC
Biological Activity: NMK-TD-100 is a modulator for microtubule. NMK-TD-100 binds to tubulin, inhibits the tubulin polymerization with an IC50 of 17.5 µM, inhibits mitosis, and decreases mitochondrial membrane potential (MMP). NMK-TD-100 inhibits the proliferation of HeLa with an IC50 of 1.42 µM, arrests cell cycle at G2/M phase, induces apoptosis in HeLa[1].
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NMK-TD-100 | NMK-TD-100 is a modulator for microtubule. NMK-TD-100 binds to tubulin, inhibits the tubulin polymerization with an IC50 of 17.5 µM, inhibits mitosis, and decreases mitochondrial membrane potential (MMP). NMK-TD-100 inhibits the proliferation of HeLa with an IC50 of 1.42 µM, arrests cell cycle at G2/M phase, induces apoptosis in HeLa. | |||||||||||||||||||||
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Keywords
