1255915-27-5
1255915-27-5
Chemical Structure
SQA1
- CAS No.: 1255915-27-5
- Formula:C22H26N4O5
- Molecular Weight:426.47
InChIKey: JSZQMZJVSCVDMA-CYBMUJFWSA-N
SMILES: OC1=C(NC2=C(N[C@H](CC)C3=CC(C(C)C)=CO3)C(C2=O)=O)C=CN=C1C(N(C)C)=O
Biological Activity: SQA1, a squaramide (SQA) derivative, is a CCR6 antagonist with a Kd of 250 nM. SQA1 is also a CXCR2 inhibitor. The intracellular pocket occupied by SQA1 overlaps with the G protein binding site and stabilizes the closed conformation of the intracellular pocket[1].
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SQA1 | SQA1, a squaramide (SQA) derivative, is a CCR6 antagonist with a Kd of 250 nM. SQA1 is also a CXCR2 inhibitor. The intracellular pocket occupied by SQA1 overlaps with the G protein binding site and stabilizes the closed conformation of the intracellular pocket. | |||||||||||||||||||||
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