1259536-70-3
1259536-70-3
Chemical Structure
QO-40
- CAS No.: 1259536-70-3
- Formula:C18H11ClF3N3O
- Molecular Weight:377.75
IUPAC Name: 5-(chloromethyl)-3-(naphthalen-1-yl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
InChIKey: RDXPGBXYEGTHBJ-UHFFFAOYSA-N
SMILES: O=C1C=C(CCl)NC2=C(C3=C4C=CC=CC4=CC=C3)C(C(F)(F)F)=NN12
Biological Activity: QO-40, a pyrazolo[1,5-a]pyrimidine-7(4H)-one (PPO) derivative, is a KCNQ2/KCNQ3 K+ channels activator with an EC50 of 6.94 μM. QO-40 stimulated Ca2+-activated K+ current (IK(Ca)) with an EC50 value of 2.3 μM in pituitary GH3 lactotrophs[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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QO-40 | 98.77% | QO-40, a pyrazolo[1,5-a]pyrimidine-7(4H)-one (PPO) derivative, is a KCNQ2/KCNQ3 K+ channels activator with an EC50 of 6.94 μM. QO-40 stimulated Ca2+-activated K+ current (IK(Ca)) with an EC50 value of 2.3 μM in pituitary GH3 lactotrophs. | ||||||||||||||||||||
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References
- [1]. Jia C, et al. Activation of KCNQ2/3 potassium channels by novel pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives. Pharmacology. 2011;87(5-6):297-310. [Content Brief]
- [2]. Chang WT, et al. Effective Activation of BKCa Channels by QO-40 (5-(Chloromethyl)-3-(Naphthalen-1-yl)-2-(Trifluoromethyl)Pyrazolo [1,5-a]pyrimidin-7(4H)-one), Known to Be an Opener of KCNQ2/Q3 Channels. Pharmaceuticals (Basel). 2021 Apr 21;14(5):388. [Content Brief]
Keywords
