1268335-33-6
Chemical Structure
AN3661
- CAS 番号: 1268335-33-6
- Formula:C10H11BO4
- Molecular Weight:206.00
IUPAC Name: 3-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yl)propanoic acid
InChIKey: CEVOKIPNIZQANN-UHFFFAOYSA-N
SMILES: O=C(O)CCC1=C(B(O)OC2)C2=CC=C1
Biological Activity: AN3661, a potent antimalarial lead compound, targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue subunit 3 (PfCPSF3). AN3661 inhibits Plasmodium falciparum laboratory-adapted strains (mean IC50=32 nM), Ugandan field isolates (mean ex vivo IC50=64 nM), and murine P. berghei and P. falciparum infections[1].
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AN3661 | 99.58% | AN3661, a potent antimalarial lead compound, targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue subunit 3 (PfCPSF3). AN3661 inhibits Plasmodium falciparum laboratory-adapted strains (mean IC50=32 nM), Ugandan field isolates (mean ex vivo IC50=64 nM), and murine P. berghei and P. falciparum infections. | ||||||||||||||||||||
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Keywords
