1274933-58-2
Chemical Structure
UE2316
- CAS No.: 1274933-58-2
- Formula:C19H17ClFN3OS
- Molecular Weight:389.87
IUPAC Name: (5-(1H-pyrazol-4-yl)thiophen-3-yl)(4-(2-chlorophenyl)-4-fluoropiperidin-1-yl)methanone
InChIKey: PLUFYVPRHFNYBR-UHFFFAOYSA-N
SMILES: O=C(C1=CSC(=C1)C=2C=NNC2)N3CCC(F)(C=4C=CC=CC4Cl)CC3
Biological Activity: UE2316 is an orally active and specific 11βHSD1 inhibitor. UE2316 significantly improves glucose tolerance and insulin sensitivity in uremic rats. UE2316 also exacerbates hepatic fibrosis in mice. UE2316 can be used in the research of diseases such as hepatic fibrosis, uremia and diabetes mellitus[1][2].
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UE2316 | UE2316 is an orally active and specific 11βHSD1 inhibitor. UE2316 significantly improves glucose tolerance and insulin sensitivity in uremic rats. UE2316 also exacerbates hepatic fibrosis in mice. UE2316 can be used in the research of diseases such as hepatic fibrosis, uremia and diabetes mellitus. | |||||||||||||||||||||
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- [1]. Zou X, et al. 11Beta-hydroxysteroid dehydrogenase-1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis. Hepatology. 2018;67(6):2167-2181. [Content Brief]
- [2]. Chapagain A, et al. Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia. Proc Natl Acad Sci U S A. 2014;111(10):3817-3822. [Content Brief]
Keywords
