128851-55-8
Chemical Structure
M 16287
- CAS No.: 128851-55-8
- Formula:C11H7ClN2O5S
- Molecular Weight:314.70
IUPAC Name: 1-((3-chlorobenzofuran-2-yl)sulfonyl)imidazolidine-2,4-dione
InChIKey: QYFQMSHWVIKPSY-UHFFFAOYSA-N
SMILES: O=C1NC(=O)CN1S(=O)(=O)C=2OC=3C=CC=CC3C2Cl
Biological Activity: M 16287 is an orally active aldose reductase inhibitor, with an IC50 of 0.08 μM in rats and 0.25 μM in cattle. M 16287 improves lens fiber swelling and vacuolization, prevents galactitol accumulation, delays inositol depletion, inhibits glutathione reduction, restores the NADPH/NADP+ ratio to normal, and normalizes lens Na+ content and Na+/K+ ratio. M 16287 prevents galactose-induced cataract formation in rats. M 16287 improves motor nerve conduction velocity in diabetic rats, partially alleviates histopathological changes in the sciatic nerve, and inhibits sorbitol accumulation. M 16287 can be used in studies related to cataracts and diabetic neuropathy[1][2].
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M 16287 | M 16287 is an orally active aldose reductase inhibitor, with an IC50 of 0.08 μM in rats and 0.25 μM in cattle. M 16287 improves lens fiber swelling and vacuolization, prevents galactitol accumulation, delays inositol depletion, inhibits glutathione reduction, restores the NADPH/NADP+ ratio to normal, and normalizes lens Na+ content and Na+/K+ ratio. M 16287 prevents galactose-induced cataract formation in rats. M 16287 improves motor nerve conduction velocity in diabetic rats, partially alleviates histopathological changes in the sciatic nerve, and inhibits sorbitol accumulation. M 16287 can be used in studies related to cataracts and diabetic neuropathy. | |||||||||||||||||||||
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- [1]. Kato K, et al. Effects of novel hydantoin derivatives with aldose reductase inhibiting activity on galactose-induced cataract in rats. Japanese journal of pharmacology. 1990 Dec;54(4):355-64. [Content Brief]
- [2]. Kato K, et al. Effects of novel aldose reductase inhibitors, M16209 and M16287, on streptozotocin-induced diabetic neuropathy in rats. European journal of pharmacology. 1991 Feb 07;193(2):185-91. [Content Brief]
Keywords
