1289638-16-9
1289638-16-9
Chemical Structure
LDN-193665
- No. CAS: 1289638-16-9
- Formula:C15H11FN4OS
- Molecular Weight:314.34
IUPAC Name: (4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(3-fluorophenyl)methanone
InChIKey: JBTRAENEEJNXFX-UHFFFAOYSA-N
SMILES: O=C(C1=C(N)N=C(NC2=CC=CN=C2)S1)C3=CC(F)=CC=C3
Biological Activity: LDN-193665 is a Tau kinase inhibitor with tauopathy-modifying activity. LDN-193665 inhibits Tau phosphorylation, improves tauopathy in animal models, reduces Sarkosyl-insoluble Tau, and restores memory. It may be necessary to simultaneously target multiple kinases to effectively inhibit tauopathies.
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LDN-193665 | LDN-193665 is a Tau kinase inhibitor with tauopathy-modifying activity. LDN-193665 inhibits Tau phosphorylation, improves tauopathy in animal models, reduces Sarkosyl-insoluble Tau, and restores memory. It may be necessary to simultaneously target multiple kinases to effectively inhibit tauopathies. | |||||||||||||||||||||
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