129075-56-5
129075-56-5
Chemical Structure
PD128763
- CAS No.: 129075-56-5
- Formula:C10H11NO
- Molecular Weight:161.20
IUPAC Name: 5-methyl-3,4-dihydroisoquinolin-1(2H)-one
InChIKey: RLLZPXDJYADIEU-UHFFFAOYSA-N
SMILES: O=C1NCCC=2C1=CC=CC2C
Biological Activity: PD128763 is a selective poly(ADP-ribose) polymerase inhibitor. PD128763 results in an enhancement of Streptozotocin (HY-13753)-induced cytotoxicity. PD128763 can be used in leukemia research[1][2].
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PD128763 | PD128763 is a selective poly(ADP-ribose) polymerase inhibitor. PD128763 results in an enhancement of Streptozotocin (HY-13753)-induced cytotoxicity. PD128763 can be used in leukemia research. | |||||||||||||||||||||
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References
- [1]. Sebolt-Leopold JS, et al. Enhancement of alkylating agent activity in vitro by PD 128763, a potent poly(ADP-ribose) synthetase inhibitor. Int J Radiat Oncol Biol Phys. 1992;22(3):619-21. [Content Brief]
- [2]. Yau L, et al. Repression of phosphoenolpyruvate carboxykinase gene activity by insulin is blocked by 3-aminobenzamide but not by PD128763, a selective inhibitor of poly(ADP-ribose) polymerase. Eur J Biochem. 1998 Apr 1;253(1):91-100. [Content Brief]
