1291868-53-5
1291868-53-5
Chemical Structure
NSF-951
Synonym(s): ZINC67299692
- CAS. Nr.: 1291868-53-5
- Formula:C23H24N4O3S
- Molecular Weight:436.53
InChIKey: HAWSEJDYICHZOB-UHFFFAOYSA-N
SMILES: O=C(CSC1=NC2=C(C(N1CC3=CC=CO3)=O)NC(C)=C2)NCC4=CC=C(CC)C=C4
Biological Activity: NSF-951 (ZINC67299692) is a TLR4 agonist (Kd = 16.01 μM). NSF-951 activates the p38 and JNK kinase pathways. NSF-951 induces IL-6 and TNF-α responses and upregulates CD80 and CD86 expression. In mouse immunization studies, NSF-951 alone or in combination with Alum enhances antigen-specific antibody and T cell responses[1].
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NSF-951 | NSF-951 (ZINC67299692) is a TLR4 agonist (Kd = 16.01 μM). NSF-951 activates the p38 and JNK kinase pathways. NSF-951 induces IL-6 and TNF-α responses and upregulates CD80 and CD86 expression. In mouse immunization studies, NSF-951 alone or in combination with Alum enhances antigen-specific antibody and T cell responses. | |||||||||||||||||||||
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