130804-35-2
130804-35-2
Chemical Structure
Lecimibide
Synonym(s): DuP 128
- CAS. Nr.: 130804-35-2
- Formula:C34H40F2N4OS
- Molecular Weight:590.77
IUPAC Name: 3-(2,4-difluorophenyl)-1-(5-((4,5-diphenyl-1H-imidazol-2-yl)thio)pentyl)-1-heptylurea
InChIKey: TVXOXGBTADZYCZ-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(F)C=C1F)N(CCCCCSC2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N2)CCCCCCC
Biological Activity: Lecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research[1][2].
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Lecimibide | Lecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research. | |||||||||||||||||||||
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References
- [1]. L J Wilcox, et al. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res. 2001 May;42(5):725-34. [Content Brief]
- [2]. J R Burnett, et al. Inhibition of cholesterol esterification by DuP 128 decreases hepatic apolipoprotein B secretion in vivo: effect of dietary fat and cholesterol. Biochim Biophys Acta. 1998 Jul 31;1393(1):63-79. [Content Brief]
