1310694-75-7
Chemical Structure
DBPR110
- CAS No.: 1310694-75-7
- Formula:C50H48N6O4S2
- Molecular Weight:861.08
IUPAC Name: N,N'-((1R,1'R)-((2S,2'S)-([1,1'-biphenyl]-4,4'-diylbis(thiazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(2-oxo-1-phenylethane-2,1-diyl))dicyclopropanecarboxamide
InChIKey: FZCLQOXUWMCXCV-XCIZVNRNSA-N
SMILES: O=C(C1CC1)N[C@H](C2=CC=CC=C2)C(N3[C@H](C4=NC=C(C5=CC=C(C6=CC=C(C7=CN=C([C@H]8N(CCC8)C([C@@H](C9=CC=CC=C9)NC(C%10CC%10)=O)=O)S7)C=C6)C=C5)S4)CCC3)=O
Biological Activity: DBPR110 is a nonstructural protein 5A (NS5A) inhibitor with inhibitory activity against hepatitis C virus (HCV). DBPR110 exhibited a 50% effective concentration (EC50) of 3.9 ± 0.9 pM and a selectivity index value of over 12,800,000 by reducing HCV1b replicon reporter expression. DBPR110 also effectively reduced the activity of HCV2a replicon with an EC50 of 228.8 pM and a selectivity index value of over 173,130. DBPR110 showed synergy with interferon alpha (IFN-α), NS3 protease inhibitors, and NS5B polymerase inhibitors. The results of DBPR110 suggest that it may be an effective small molecule inhibitor against HCV NS5A[1].
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DBPR110 | DBPR110 is a nonstructural protein 5A (NS5A) inhibitor with inhibitory activity against hepatitis C virus (HCV). DBPR110 exhibited a 50% effective concentration (EC50) of 3.9 ± 0.9 pM and a selectivity index value of over 12,800,000 by reducing HCV1b replicon reporter expression. DBPR110 also effectively reduced the activity of HCV2a replicon with an EC50 of 228.8 pM and a selectivity index value of over 173,130. DBPR110 showed synergy with interferon alpha (IFN-α), NS3 protease inhibitors, and NS5B polymerase inhibitors. The results of DBPR110 suggest that it may be an effective small molecule inhibitor against HCV NS5A. | |||||||||||||||||||||
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Keywords
