131084-35-0
Chemical Structure
CP94253
- CAS No.: 131084-35-0
- Formula:C15H19N3O
- Molecular Weight:257.33
IUPAC Name: 5-propoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[3,2-b]pyridine
InChIKey: KWQWBZIGHIOKIO-UHFFFAOYSA-N
SMILES: CCCOC1=NC2=C(NC=C2C3=CCNCC3)C=C1
Biological Activity: CP94253 is an orally active, brain-penetrant and selective 5-HT1B receptor agonist with an Ki of 2 nM. CP94253 induces antidepressant-like effects, waking enhancement, sleep inhibition, increased sleep latency, hyperlocomotion, and suppressed aggressive behavior. CP94253 can be used for the research of depression and heightened aggressive behavior[1][2][3][4][5][6].
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CP94253 | CP94253 is an orally active, brain-penetrant and selective 5-HT1B receptor agonist with an Ki of 2 nM. CP94253 induces antidepressant-like effects, waking enhancement, sleep inhibition, increased sleep latency, hyperlocomotion, and suppressed aggressive behavior. CP94253 can be used for the research of depression and heightened aggressive behavior. | |||||||||||||||||||||
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- [1]. Schreiber R, et al. Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2002;26(3):441-449. [Content Brief]
- [2]. Tatarczyńska E, et al. Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action. Eur J Pharmacol. 2005;516(1):46-50. [Content Brief]
- [3]. Monti JM, et al. Effects of selective activation of the 5-HT1B receptor with CP-94,253 on sleep and wakefulness in the rat. Neuropharmacology. 1995 Dec;34(12):1647-51. [Content Brief]
- [4]. Koe KB, et al. Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Dev. Res. 1992;26:241-250.
- [5]. Fish EW, et al. Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT(1B) receptor agonist CP-94,253. Psychopharmacology (Berl). 1999;146(4):391-399. [Content Brief]
- [6]. Lee MD, et al. CP-94, 253: a selective serotonin1B (5-HT1B) agonist that promotes satiety. Psychopharmacology (Berl). 1997;131(3):264-270. [Content Brief]
Keywords
