1314212-39-9
1314212-39-9
Chemical Structure
CYM50358
- CAS No.: 1314212-39-9
- Formula:C20H18Cl2N2O2
- Molecular Weight:389.28
IUPAC Name: N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide
InChIKey: QWJOPXDAQCDRRM-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C2=CC(Cl)=CC=C2Cl)O1)NC3=C(C)C=C(CN)C=C3C
Biological Activity: CYM50358 is a potent and selective S1PR4 antagonist, with an IC50 of 25 nM. CYM50358 can be used for the research of influenza infection[1][2].
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CYM50358 | 98.33% | CYM50358 is a potent and selective S1PR4 antagonist, with an IC50 of 25 nM. CYM50358 can be used for the research of influenza infection. | ||||||||||||||||||||
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References
- [1]. Guerrero M, et, al. Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3632-6. [Content Brief]
- [2]. Onuma T, et, al. Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. Thromb Res. 2017 Aug;156:91-100. [Content Brief]
