133538-58-6
133538-58-6
Chemical Structure
I-SAP
- CAS No.: 133538-58-6
- Formula:C22H30INO4S
- Molecular Weight:531.45
IUPAC Name: (Z)-7-((1S,3S,5R)-3-((4-iodophenyl)sulfonamido)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)hept-5-enoic acid
InChIKey: SZNMERGTFJHNSM-JAWYFFTGSA-N
SMILES: OC(CCC/C=C\C[C@H]1[C@@](C[C@]2([H])C[C@@H]1N[S](=O)(C(C=C3)=CC=C3I)=O)([H])C2(C)C)=O
Biological Activity: I-SAP is a radioiodinated TXA2/PGH2 receptor antagonist. The bind between I-SAP and the receptors, is inhibited by the histidine modifying reagent diethyl-pyrocarbonate (DEPC)[1][2].
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I-SAP | I-SAP is a radioiodinated TXA2/PGH2 receptor antagonist. The bind between I-SAP and the receptors, is inhibited by the histidine modifying reagent diethyl-pyrocarbonate (DEPC). | |||||||||||||||||||||
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References
- [1]. Saussy DL Jr, et al. Binding of a novel radioiodinated thromboxane A2/prostaglandin H2 antagonist to guinea pig lung membranes. Eicosanoids. 1992;5(1):1-4. [Content Brief]
- [2]. Schrör K, et al. Inhibition of ligand binding to thromboxane A2/prostaglandin H2 receptors by diethylpyrocarbonate. Protection by receptor ligands and reversal by hydroxylamine. Biochem Pharmacol. 1995 Mar 30;49(7):921-7. [Content Brief]
