133658-45-4
Chemical Structure
Anantin
- CAS No.: 133658-45-4
- Formula:C90H111N21O24
- Molecular Weight:1870.97
InChIKey: PXMKNCAIFBQHPS-WKRAVPHXSA-N
SMILES: O=C(CNC([C@](NC([C@@H](NC(CNC(C[C@H](NC([C@@H](NC(CNC1=O)=O)CC(N)=O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CO)C(NCC(N[C@@H](CC(O)=O)C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)CC3=CC=C(C=C3)O)=O)CC4=CN=CN4)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)CC6=CC=CC=C6)=O)([H])[C@@H](C)CC)=O)N[C@H]1CC7=CNC8=CC=CC=C78
Biological Activity: Anantin binds competitively to the receptor of atrial natriuretic factor (ANF) from bovine adrenal cortex (Kd = 0.6 μM) and acts as natriuretic peptide receptor A antagonist[1][2].
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Anantin | Anantin binds competitively to the receptor of atrial natriuretic factor (ANF) from bovine adrenal cortex (Kd = 0.6 μM) and acts as natriuretic peptide receptor A antagonist. | |||||||||||||||||||||
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- [1]. Wyss DF,et al. Anantin--a peptide antagonist of the atrial natriuretic factor (ANF). II. Determination of the primary sequence by NMR on the basis of proton assignments. J Antibiot (Tokyo). 1991 Feb;44(2):172-80.https://pubmed.ncbi.nlm.nih.gov/1826288/1. Wyss DF,et al. Anantin--a peptide antagonist of the atrial natriuretic factor (ANF). II. Determination of the primary sequence by NMR on the basis of proton assignments. J Antibiot (Tokyo). 1991 Feb;44(2):172-80. [Content Brief]
- [2]. Nachshon S, et al. Effects of ANP receptor antagonists on ANP secretion from adult rat cultured atrial myocytes. Am J Physiol. 1995 Mar;268(3 Pt 1):E428-32. [Content Brief]
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