133903-90-9
Chemical Structure
ME 3407
Synonym(s): EF-4040
- CAS. Nr.: 133903-90-9
- Formula:C12H14N2O3S2
- Molecular Weight:298.38
IUPAC Name: butyl 2-(thiazolo[5,4-b]pyridin-2-ylsulfinyl)acetate
InChIKey: BUXNKFNNJJTLOS-UHFFFAOYSA-N
SMILES: O=C(OCCCC)CS(C1=NC2=CC=CN=C2S1)=O
Biological Activity: ME-3407 (EF-4040) is a H+-K+-ATPase redistribution disruptor and myosin light chain kinase (MLCK) and protein kinase A inhibitor. ME-3407 blocks gastric acid secretion and aminopyrine accumulation by inhibiting microsomal-to-apical membrane redistribution of H+-K+-ATPase and suppressing MLCK-mediated myosin light chain phosphorylation. ME-3407 is promising for research of peptic ulcer[1].
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ME 3407 | ME-3407 (EF-4040) is a H+-K+-ATPase redistribution disruptor and myosin light chain kinase (MLCK) and protein kinase A inhibitor. ME-3407 blocks gastric acid secretion and aminopyrine accumulation by inhibiting microsomal-to-apical membrane redistribution of H+-K+-ATPase and suppressing MLCK-mediated myosin light chain phosphorylation. ME-3407 is promising for research of peptic ulcer. | |||||||||||||||||||||
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