1341007-95-1
Chemical Structure
E234G HYPE-IN-1
- CAS No.: 1341007-95-1
- Formula:C14H9N5O2
- Molecular Weight:279.25
InChIKey: ODJVBWZFCWFPCB-UHFFFAOYSA-N
SMILES: C1(N2C=CN=C2)=NC=C(C3=NN=C(C4=COC=C4)O3)C=C1
Biological Activity: E234G HYPE-IN-1 (Compound I2.10) is an inhibitor of AMPylation directed by the Huntingtin-interacting protein E (HYPE), possessing low micromolar bioactivity, low cytotoxicity, and blood-brain barrier permeability. E234G HYPE-IN-1 can inhibit the AMPylation of B-cell immunoglobulin-binding protein (BiP), the primary substrate of HYPE. E234G HYPE-IN-1 is suitable for development as a HYPE-specific therapeutic agent for clinical conditions such as neurodegenerative diseases and diabetes[1].
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E234G HYPE-IN-1 | E234G HYPE-IN-1 (Compound I2.10) is an inhibitor of AMPylation directed by the Huntingtin-interacting protein E (HYPE), possessing low micromolar bioactivity, low cytotoxicity, and blood-brain barrier permeability. E234G HYPE-IN-1 can inhibit the AMPylation of B-cell immunoglobulin-binding protein (BiP), the primary substrate of HYPE. E234G HYPE-IN-1 is suitable for development as a HYPE-specific therapeutic agent for clinical conditions such as neurodegenerative diseases and diabetes. | |||||||||||||||||||||
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Keywords
