134470-38-5
Chemical Structure
BW B70C
- CAS No.: 134470-38-5
- Formula:C17H17FN2O3
- Molecular Weight:316.33
IUPAC Name: (E)-1-(4-(3-(4-fluorophenoxy)phenyl)but-3-en-2-yl)-1-hydroxyurea
InChIKey: UAIYNMRLUHHRMF-AATRIKPKSA-N
SMILES: O=C(N)N(C(C)/C=C/C1=CC=CC(OC2=CC=C(F)C=C2)=C1)O
Biological Activity: BW B70C is a potent, selective and orally activearachidonic acid 5-lipoxygenase inhibitor. BW B70C inhibits both acute and allergic bronchoconstriction and late-phase eosinophil accumulation subsequent to allergen inhalation in guinea-pigs. BW B70C prevents leukotriene C4 synthesis and reduces leucocyte migration to the airways lumen as well as albumin microvascular leakage. BW B70C has the potential for the research of anti-asthma agent[1][2][3].
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BW B70C | BW B70C is a potent, selective and orally activearachidonic acid 5-lipoxygenase inhibitor. BW B70C inhibits both acute and allergic bronchoconstriction and late-phase eosinophil accumulation subsequent to allergen inhalation in guinea-pigs. BW B70C prevents leukotriene C4 synthesis and reduces leucocyte migration to the airways lumen as well as albumin microvascular leakage. BW B70C has the potential for the research of anti-asthma agent. | |||||||||||||||||||||
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References
- [1]. Yeadon M, et al. Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. Agents Actions. 1993 Jan;38(1-2):8-18. [Content Brief]
- [2]. Bureau MF, et al. 5-Lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs. Eur J Pharmacol. 1997 Apr 11;324(1):89-98. [Content Brief]
- [3]. Payne AN, et al. Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 1991;34:189-99. [Content Brief]
