134516-99-7
Chemical Structure
U-90042
- CAS No.: 134516-99-7
- Formula:C17H13ClN6O
- Molecular Weight:352.78
IUPAC Name: 3-(11-chloro-2,3-dihydrodiimidazo[1,5-a:1',2'-c]quinazolin-5-yl)-5-cyclopropyl-1,2,4-oxadiazole
InChIKey: CLPSAAPUJUVQPP-UHFFFAOYSA-N
SMILES: ClC1=CC(C2=NCCN2C3=C(C4=NOC(C5CC5)=N4)N=CN63)=C6C=C1
Biological Activity: U-90042 is a gamma-aminobutyric acidA receptor agonist of α1, α3 and α6 subtypes with Ki values of 7.8 nM, 9.5 nM and 11.0 nM, respectively. U-90042 suppresses locomotor activity and impairs rotarod performance in mice. U-90042 produces sedation and ataxia and prolongs sleeping time in mice, rats and monkeys. U-90042 can be used as a sedative and hypnotic agent[1].
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U-90042 | U-90042 is a gamma-aminobutyric acidA receptor agonist of α1, α3 and α6 subtypes with Ki values of 7.8 nM, 9.5 nM and 11.0 nM, respectively. U-90042 suppresses locomotor activity and impairs rotarod performance in mice. U-90042 produces sedation and ataxia and prolongs sleeping time in mice, rats and monkeys. U-90042 can be used as a sedative and hypnotic agent. | |||||||||||||||||||||
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Keywords
