134557-41-8
Chemical Structure
PD-135666
- CAS No.: 134557-41-8
- Formula:C33H39N3O5
- Molecular Weight:557.68
IUPAC Name: (S)-3-((R)-2-(((adamantan-2-yloxy)carbonyl)amino)-3-(1H-indol-3-yl)-2-methylpropanamido)-4-phenylbutanoic acid
InChIKey: PGOLWKTUHWHYJS-SFMDGOMNSA-N
SMILES: O=C(C[C@H](CC1=CC=CC=C1)NC([C@](NC(OC2C3CC4CC(CC2C4)C3)=O)(CC5=CNC6=C5C=CC=C6)C)=O)O
Biological Activity: PD-135666 is a dipeptide inhibitor of cholecystokinin B (CCK B) receptors, binding to CCK B receptors in mouse cerebral cortex with IC50 of 0.1 nM. Its enantiomer, PD-140548, preferentially binds to CCK A receptors with IC50 of 2.8 nM in rat pancreas. PD-135666 exhibits anxiolytic effects in animal models[1].
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PD-135666 | PD-135666 is a dipeptide inhibitor of cholecystokinin B (CCK B) receptors, binding to CCK B receptors in mouse cerebral cortex with IC50 of 0.1 nM. Its enantiomer, PD-140548, preferentially binds to CCK A receptors with IC50 of 2.8 nM in rat pancreas. PD-135666 exhibits anxiolytic effects in animal models. | |||||||||||||||||||||
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Keywords
