1350852-88-8
1350852-88-8
Chemical Structure
SGC stimulator 2
- CAS No.: 1350852-88-8
- Formula:C24H18ClF5N6O
- Molecular Weight:536.88
InChIKey: CEAKUUHMQPRRMO-QFIPXVFZSA-N
SMILES: ClC1=CC2=C(C=C1)C(C3=NC(NC([C@@]4(C)C5=CC=CC=C5)=O)=C4C(N)=N3)=NN2CCC(F)(F)C(F)(F)F
Biological Activity: SGC stimulator 2 is an orally active soluble guanylyl cyclase (sGC) stimulator with an EC50 of 44 nM. SGC stimulator 2 exhibits inhibitory activity against the CB2 receptor, with an IC50 of 2.7 μM. SGC stimulator 2 activates native (Fe2+) sGC in a heme-dependent manner. SGC stimulator 2 produces sustained hypotensive effects in animal models. SGC stimulator 2 can be used for the research of hypertension[1].
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SGC stimulator 2 | SGC stimulator 2 is an orally active soluble guanylyl cyclase (sGC) stimulator with an EC50 of 44 nM. SGC stimulator 2 exhibits inhibitory activity against the CB2 receptor, with an IC50 of 2.7 μM. SGC stimulator 2 activates native (Fe2+) sGC in a heme-dependent manner. SGC stimulator 2 produces sustained hypotensive effects in animal models. SGC stimulator 2 can be used for the research of hypertension. | |||||||||||||||||||||
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