135133-84-5
Chemical Structure
SC-45662
- CAS No.: 135133-84-5
- Formula:C20H32O4S
- Molecular Weight:368.53
IUPAC Name: 2-(((2S,3R)-3-((3,5-di-tert-butyl-4-hydroxyphenyl)thio)butan-2-yl)oxy)acetic acid
InChIKey: ADVNUIUADIXWMI-QWHCGFSZSA-N
SMILES: O=C(O)CO[C@@H](C)[C@H](SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)C
Biological Activity: SC-45662 is a 5-lipoxygenase inhibitor. SC-45662 inhibits the response of monocytes to phytohemagglutinin (PHA). SC-45662 inhibits superoxide production in neutrophils. SC-45662 slows early changes in lung mechanics and pulmonary hypertension in a sheep model of impaired lung function. SC-45662 can be used in research on diseases of the immune system, respiratory system, etc[1][2][3].
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SC-45662 | SC-45662 is a 5-lipoxygenase inhibitor. SC-45662 inhibits the response of monocytes to phytohemagglutinin (PHA). SC-45662 inhibits superoxide production in neutrophils. SC-45662 slows early changes in lung mechanics and pulmonary hypertension in a sheep model of impaired lung function. SC-45662 can be used in research on diseases of the immune system, respiratory system, etc. | |||||||||||||||||||||
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- [1]. Weir MR, et al. The immunosuppressive properties of enisoprost and a 5-lipoxygenase inhibitor (SC-45662). Transplantation. 1991 Dec;52(6):1053-7. [Content Brief]
- [2]. Kocan GP, et al. Contrasting effects of two arachidonate 5-lipoxygenase inhibitors on formyl-methionyl-leucyl-phenylalanine (fMLP) and complement fragment 5a induced human neutrophil superoxide generation. Biochem Pharmacol. 1994 Mar 15;47(6):1029-37. [Content Brief]
- [3]. Kuratomi Y,et al. Effect of a 5-lipoxygenase inhibitor on endotoxin-induced pulmonary dysfunction in awake sheep. J Appl Physiol (1985). 1993 Feb;74(2):596-605. [Content Brief]
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