1353016-70-2
1353016-70-2
Chemical Structure
DBCO-acid
- CAS No.: 1353016-70-2
- Formula:C19H15NO3
- Molecular Weight:305.33
InChIKey: NDLOVDOICXITOK-UHFFFAOYSA-N
SMILES: O=C(CCC(O)=O)N(C1)C2=C(C=CC=C2)C#CC3=C1C=CC=C3
Biological Activity: DBCO-acid is a click chemistry reagent used in the synthesis of ADC linker DBCO-NHS ester ((HY-115524) and (HY-115545)), and agent-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690). DBCO-acid contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DBCO-acid | 99.90% | DBCO-acid is a click chemistry reagent used in the synthesis of ADC linker DBCO-NHS ester ((HY-115524) and (HY-115545)), and agent-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690). DBCO-acid contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | ||||||||||||||||||||
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DBCO-acid (GMP) | DBCO-acid GMP is a GMP grade DBCO-acid (HY-42972). DBCO-acid is a click chemistry reagent used in the synthesis of ADC linker DBCO-NHS ester ((HY-115524) and (HY-115545)), and agent-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690). DBCO-acid contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | |||||||||||||||||||||
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References
- [1]. Zimmerman ES, et al. Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system. Bioconjug Chem. 2014 Feb 19;25(2):351-61. [Content Brief]
- [2]. Klein PM, et al. Click-Shielded and Targeted Lipopolyplexes. Methods Mol Biol. 2019;2036:141-164. [Content Brief]
- [3]. Wang M, et al. Transforms of Cell Surface Glycoproteins Charge Influences Tumor Cell Metastasis via Atypically Inhibiting Epithelial-Mesenchymal Transition Including Matrix Metalloproteinases and Cell Junctions. Bioconjug Chem. 2023 Aug 16;34(8):1498-1507. [Content Brief]
- [4]. Klein PM, et al. Folate receptor-directed orthogonal click-functionalization of siRNA lipopolyplexes for tumor cell killing in vivo. Biomaterials. 2018 Sep;178:630-642. [Content Brief]
