1355228-39-5
1355228-39-5
Chemical Structure
K812
- CAS No.: 1355228-39-5
- Formula:C30H27N3O5
- Molecular Weight:509.55
InChIKey: WFDAQNSWGDXBKO-UHFFFAOYSA-N
SMILES: O=C(C1=CN(C(C)C)C2=C(C1=O)C=CC=C2)NC3=CC=C(C=C3)OC4=C5C=C(OC)C(OC)=CC5=NC=C4
Biological Activity: K812 is an orally active ASK1 inhibitor with a 6 nM IC50 against ASK1. K812 selectively inhibits ASK1 activation. K812 inhibits glial activation in the lumbar spinal cord. K812 extends survival of SOD1G93A transgenic mice. K812 can be used for the research of amyotrophic lateral sclerosis[1].
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K812 | K812 is an orally active ASK1 inhibitor with a 6 nM IC50 against ASK1. K812 selectively inhibits ASK1 activation. K812 inhibits glial activation in the lumbar spinal cord. K812 extends survival of SOD1G93A transgenic mice. K812 can be used for the research of amyotrophic lateral sclerosis. | |||||||||||||||||||||
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References
Keywords
