136449-85-9
Chemical Structure
NPC-15437
- CAS No.: 136449-85-9
- Formula:C25H50N4O2
- Molecular Weight:438.70
IUPAC Name: (2S)-2,6-diamino-N-((1-tridecanoylpiperidin-2-yl)methyl)hexanamide
InChIKey: HXQRGYNEDCHJPJ-WCSIJFPASA-N
SMILES: C(NC([C@H](CCCCN)N)=O)C1N(C(CCCCCCCCCCCC)=O)CCCC1
Biological Activity: NPC-15437 is a selective PKC inhibitor with an IC50 of 19 µM. NPC-15437 competitively inhibits phorbol ester- (Ki of 5 µM) and phosphatidylserine-induced (Ki of 12 µM) PKC activity. NPC-15437 does not inhibits cAMP-dependent or calcium/calmodulin-dependent protein kinases. NPC-15437 augments TRAIL-induced cell death in non-small cell lung cancer and medulloblastoma cells. NPC-15437 can be used for the research of non-small cell lung cancer, medulloblastoma, and neurological disease[1][2][3][4].
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NPC-15437 | NPC-15437 is a selective PKC inhibitor with an IC50 of 19 µM. NPC-15437 competitively inhibits phorbol ester- (Ki of 5 µM) and phosphatidylserine-induced (Ki of 12 µM) PKC activity. NPC-15437 does not inhibits cAMP-dependent or calcium/calmodulin-dependent protein kinases. NPC-15437 augments TRAIL-induced cell death in non-small cell lung cancer and medulloblastoma cells. NPC-15437 can be used for the research of non-small cell lung cancer, medulloblastoma, and neurological disease. | |||||||||||||||||||||
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References
- [1]. Aujla H, et al. Intra-accumbens protein kinase C inhibitor NPC 15437 blocks amphetamine-produced conditioned place preference in rats. Behav Brain Res. 2003;147(1-2):41-48. [Content Brief]
- [2]. Mathis C, et al. The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice. Eur J Pharmacol. 1992;220(1):107-110. [Content Brief]
- [3]. Felber M, et al. Inhibition of novel protein kinase C-epsilon augments TRAIL-induced cell death in A549 lung cancer cells. Pathol Oncol Res. 2007;13(4):295-301. [Content Brief]
- [4]. Sullivan JP, et al. 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain. Mol Pharmacol. 1992 Jan;41(1):38-44. [Content Brief]
