137593-43-2
Chemical Structure
Glutathione maleimide
Synonym(s): GS-Mal
- CAS No.: 137593-43-2
- Formula:C14H17N3O8S
- Molecular Weight:387.37
InChIKey: RLINWINCQATEGU-YUMQZZPRSA-N
SMILES: OC(CNC([C@H](CS)NC(CC[C@H](N1C(C=CC1=O)=O)C(O)=O)=O)=O)=O
Biological Activity: Glutathione maleimide (GS-Mal) is a glutathione depletor and oxidative stress inducer that reduces intracellular GSH levels in cancer cells and induces apoptosis. Glutathione maleimide can selectively extract and quantify GSH from complex biological samples, and the polymeric micelles prepared from it also inhibit the growth of cancer cells in a concentration-dependent manner. Glutathione maleimide has broad applications in breast cancer and related fields[1][2].
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Glutathione maleimide | Glutathione maleimide (GS-Mal) is a glutathione depletor and oxidative stress inducer that reduces intracellular GSH levels in cancer cells and induces apoptosis. Glutathione maleimide can selectively extract and quantify GSH from complex biological samples, and the polymeric micelles prepared from it also inhibit the growth of cancer cells in a concentration-dependent manner. Glutathione maleimide has broad applications in breast cancer and related fields. | |||||||||||||||||||||
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- [1]. Oh H, Lee J, Yeo W S. Selective Extraction and Quantification of Glutathione using Maleimide-Presenting Gold Nanoparticles[J]. Bulletin of the Korean Chemical Society, 2014, 35(10): 3047. [Content Brief]
- [2]. Babanyinah GK, et al.. Maleimide functionalized polycaprolactone micelles for glutathione quenching and doxorubicin delivery. Chemical science. 2024 Jul 03;15(26):9987-10001. [Content Brief]
Keywords
