1377605-22-5
Chemical Structure
Biotinylated isoxazole
- CAS No.: 1377605-22-5
- Formula:C24H32N4O5S2
- Molecular Weight:520.66
IUPAC Name: 6-(5-(thiophen-2-yl)isoxazole-3-carboxamido)hexyl 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate
InChIKey: KZZXSHXZDYGEDW-XJABCFGWSA-N
SMILES: O=C(C1=NOC(C2=CC=CS2)=C1)NCCCCCCOC(CCCC[C@H]3[C@]4([H])[C@](NC(N4)=O)([H])CS3)=O
Biological Activity: Biotinylated isoxazole is a chemical probe that selectively precipitates proteins containing prion-like low-complexity domains and Cross-β prion-like polymers through recognition of Cross-β structure. Biotinylated isoxazole induces precipitation of proteins containing intrinsically disordered regions through microcrystal formation in solution. Biotinylated isoxazole enables enrichment of Amyloid oligomers for ELISA-based detection. Biotinylated isoxazole decreases Gems and increases misfolded PFN1 aggregates[1][2][3][4][5][6].
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Biotinylated isoxazole | 99.41% | Biotinylated isoxazole is a chemical probe that selectively precipitates proteins containing prion-like low-complexity domains and Cross-β prion-like polymers through recognition of Cross-β structure. Biotinylated isoxazole induces precipitation of proteins containing intrinsically disordered regions through microcrystal formation in solution. Biotinylated isoxazole enables enrichment of Amyloid oligomers for ELISA-based detection. Biotinylated isoxazole decreases Gems and increases misfolded PFN1 aggregates. | ||||||||||||||||||||
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Biotinylated isoxazole (Standard) | ≥98% | Biotinylated isoxazole (Standard) is the analytical standard of Biotinylated isoxazole (HY-W750960). This product is intended for research and analytical applications. Biotinylated isoxazole is a chemical probe that selectively precipitates proteins containing prion-like low-complexity domains and Cross-β prion-like polymers through recognition of Cross-β structure. Biotinylated isoxazole induces precipitation of proteins containing intrinsically disordered regions through microcrystal formation in solution. Biotinylated isoxazole enables enrichment of Amyloid oligomers for ELISA-based detection. Biotinylated isoxazole decreases Gems and increases misfolded PFN1 aggregates. | ||||||||||||||||||||
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References
- [1]. Hansen HT, et al. Drosophila Imp iCLIP identifies an RNA assemblage coordinating F-actin formation. Genome biology. 2015 Jun 9;16(1):123.
- [2]. Terlecki-Zaniewicz S, et al. Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression. Nature structural & molecular biology. 2021 Feb;28(2):190-201.
- [3]. Wang I F, et al. Visualizing Molecular Alterations and Peripheral Detections in Asymptomatic Amyotrophic Lateral Sclerosis Using b-isox-based Detection[J]. 2024.
- [4]. Wang I F, et al. Precisely Correcting SMN Deficiency Pathways in Spinal Muscular Atrophy Using an Off-Amyloid Stabilizer[J]. 2024.
- [5]. Wang I F, et al. Prion-like Conformational Editing of SMN2 Proteins Rescues Spinal Muscular Atrophy[J]. 2021.
- [6]. Cheng H C M. Characterization of RNA Granules in Muscle Stem Cells through TACC3 and DDX6[M]. McGill University (Canada), 2022.
