1382354-18-8
1382354-18-8
Chemical Structure
NCO-90
- CAS No.: 1382354-18-8
- Formula:C21H20N2O2
- Molecular Weight:332.40
InChIKey: VVRUXFPJOVUDCV-UHFFFAOYSA-N
SMILES: O=C(C1=C(NC2=CC(OCCC3=CC=CC=C3)=CC=C2)C=CC=C1)N
Biological Activity: NCO-90 is a selective SIRT2 inhibitor with an IC50 of 1.0 μM. NCO-90 induces Apoptosis via Caspase activation and mitochondrial superoxide anion production, and also induces Autophagic cell death by increasing LC3-II levels and autophagosome accumulation. NCO-90 exhibits anticancer activity against leukemia. NCO-90 can be used in research related to acute lymphoblastic leukemia and acute myeloid leukemia[1][2].
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NCO-90 | NCO-90 is a selective SIRT2 inhibitor with an IC50 of 1.0 μM. NCO-90 induces Apoptosis via Caspase activation and mitochondrial superoxide anion production, and also induces Autophagic cell death by increasing LC3-II levels and autophagosome accumulation. NCO-90 exhibits anticancer activity against leukemia. NCO-90 can be used in research related to acute lymphoblastic leukemia and acute myeloid leukemia. | |||||||||||||||||||||
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References
- [1]. Itoh Y. Drug Discovery Researches on Modulators of Lysine-Modifying Enzymes Based on Strategic Chemistry Approaches. Chem Pharm Bull (Tokyo). 2020;68(1):34-45. [Content Brief]
- [2]. Kozako T, et al. Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines. BMC Cancer. 2018;18(1):791. Published 2018 Aug 6. [Content Brief]
