139896-80-3
Chemical Structure
PSB-1737
- CAS. Nr.: 139896-80-3
- Formula:C18H15NO5
- Molecular Weight:325.32
IUPAC Name: 3-(2-carboxyethyl)-6-phenoxy-1H-indole-2-carboxylic acid
InChIKey: PKFAYNLUAGDMNZ-UHFFFAOYSA-N
SMILES: O=C(C1=C(CCC(O)=O)C2=C(C=C(C=C2)OC3=CC=CC=C3)N1)O
Biological Activity: PSB-1737 is a human-selective GPR17 agonist with an EC50 for human GPR17 of 270 nM, and its activity on murine GPR17 is relatively weak (EC50 > 10 μM). PSB-1737 shows no significant inhibition at the glycine binding site of NMDA receptors, and has no significant agonistic or antagonistic activity on P2Y receptor subtypes. PSB-1737 can be used in demyelinating diseases (such as multiple sclerosis) or inflammatory-related anemia[1].
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PSB-1737 | PSB-1737 is a human-selective GPR17 agonist with an EC50 for human GPR17 of 270 nM, and its activity on murine GPR17 is relatively weak (EC50 > 10 μM). PSB-1737 shows no significant inhibition at the glycine binding site of NMDA receptors, and has no significant agonistic or antagonistic activity on P2Y receptor subtypes. PSB-1737 can be used in demyelinating diseases (such as multiple sclerosis) or inflammatory-related anemia. | |||||||||||||||||||||
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