1403602-92-5
Chemical Structure
GSK729
- CAS No.: 1403602-92-5
- Formula:C16H16F3N3O2
- Molecular Weight:339.31
IUPAC Name: (5R,7S)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid
InChIKey: PZUHMVXZBLEHFM-OLZOCXBDSA-N
SMILES: O=C(O)C1=C2N[C@H](C[C@H](N2N=C1)C(F)(F)F)C3=CC=C(C=C3)CC
Biological Activity: GSK729 is a THPP inhibitor with the activity of inhibiting EchA6 and inhibiting Mycobacterium tuberculosis. GSK729 can selectively pull down EchA6 in a stereospecific manner, inhibit its activity, inhibit fatty acid synthesis of Mycobacterium tuberculosis, and has a bactericidal effect in a mouse chronic tuberculosis infection model.
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GSK729 | GSK729 is a THPP inhibitor with the activity of inhibiting EchA6 and inhibiting Mycobacterium tuberculosis. GSK729 can selectively pull down EchA6 in a stereospecific manner, inhibit its activity, inhibit fatty acid synthesis of Mycobacterium tuberculosis, and has a bactericidal effect in a mouse chronic tuberculosis infection model. | |||||||||||||||||||||
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Keywords
