140695-21-2
Chemical Structure
Osutidine
- CAS No.: 140695-21-2
- Formula:C19H28N4O5S2
- Molecular Weight:456.58
IUPAC Name: (E)-N-(N-(2-hydroxy-2-(4-hydroxyphenyl)ethyl)-N'-(2-(((5-((methylamino)methyl)furan-2-yl)methyl)thio)ethyl)carbamimidoyl)methanesulfonamide
InChIKey: GZPOYVTZKHVRHE-UHFFFAOYSA-N
SMILES: OC(C1=CC=C(O)C=C1)CN/C(NS(C)(=O)=O)=N\CCSCC2=CC=C(CNC)O2
Biological Activity: Osutidine is a selective histamine H2 receptor antagonist, can effectively inhibit histamine-stimulated gastric acid secretion. Osutidine does not affect [14C]aminopyrine accumulation stimulated by carbachol or dibutyryl-cAMP. Osutidine is insurmountable and includes non-competitive inhibition. Osutidine can be used for the study of gastric mucosal injury[1][2].
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Osutidine | Osutidine is a selective histamine H2 receptor antagonist, can effectively inhibit histamine-stimulated gastric acid secretion. Osutidine does not affect [14C]aminopyrine accumulation stimulated by carbachol or dibutyryl-cAMP. Osutidine is insurmountable and includes non-competitive inhibition. Osutidine can be used for the study of gastric mucosal injury. | |||||||||||||||||||||
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References
- [1]. Inoie M, et al. Histamine H2-receptor antagonism of Osutidine, an anti-ulcer agent: studies on aminopyrine accumulation in isolated canine gastric mucosal cells. Jpn J Pharmacol. 1998 Nov;78(3):313-22. [Content Brief]
- [2]. Tsuji S, et al. Effects of osutidine (T-593) and its enantiomers on gastric mucosal hemodynamics and mucosal integrity in anesthetized rats. Arzneimittelforschung. 2001 Jan;51(1):46-50. [Content Brief]
