141533-35-9
141533-35-9
Chemical Structure
SDZ 216-525
- CAS. Nr.: 141533-35-9
- Formula:C25H28N4O5S
- Molecular Weight:496.58
IUPAC Name: methyl 4-(4-(4-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)butyl)piperazin-1-yl)-1H-indole-2-carboxylate
InChIKey: LPPRLWFUMJHAKF-UHFFFAOYSA-N
SMILES: O=C(C(N1)=CC2=C1C=CC=C2N3CCN(CCCCN(C(C4=C5C=CC=C4)=O)S5(=O)=O)CC3)OC
Biological Activity: SDZ 216-525 is a selective silent antagonist of 5-HT1A receptor[1][2].
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SDZ 216-525 | SDZ 216-525 is a selective silent antagonist of 5-HT1A receptor. | |||||||||||||||||||||
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References
- [1]. Boddeke H W G M, et al. Agonist/antagonist interactions with cloned human 5-HT 1A receptors: variations in intrinsic activity studied in transfected HeLa cells[J]. Naunyn-Schmiedeberg's archives of pharmacology, 1992, 345: 257-263. [Content Brief]
- [2]. Sharp T, et al. The novel 5‐HT1A receptor antagonist, SDZ 216–525, decreases 5‐HT release in rat hippocampus in vivo[J]. British journal of pharmacology, 1993, 109(3): 699-702. [Content Brief]
Keywords
