1417630-95-5
Chemical Structure
PIM1-IN-1
- CAS No.: 1417630-95-5
- Formula:C25H30N8O2
- Molecular Weight:474.56
IUPAC Name: 2-(7-(2-methoxyethyl)-8,9-dihydro-7H-[1,2,4]triazolo[4',3':2,3]pyridazino[4,5-b][1,4]oxazin-3-yl)-N-(piperidin-4-ylmethyl)quinolin-8-amine
InChIKey: BKDLGAKRAHVMNP-UHFFFAOYSA-N
SMILES: COCCN1C2=C(C3=NN=C(C4=NC5=C(NCC6CCNCC6)C=CC=C5C=C4)N3N=C2)OCC1
Biological Activity: PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity[1].
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PIM1-IN-1 | 99.83% | PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity. | ||||||||||||||||||||
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PIM1-IN-1 (Standard) | ≥98% | PIM1-IN-1 (Standard) is the analytical standard of PIM1-IN-1 (HY-111552). This product is intended for research and analytical applications. PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity. | ||||||||||||||||||||
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