1427515-26-1
Chemical Structure
Gymnin
- CAS No.: 1427515-26-1
- Formula:C48H74N12O20S
- Molecular Weight:1171.23
InChIKey: NSPKLGFZFLTJBG-RRHNWJSNSA-N
SMILES: O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CS)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CC=C(C=C1)O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Biological Activity: Gymnin is a defensin-like antifungal peptide. Gymnin has significant antifungal activities against phytopathogenic and mycotoxigenic fungi. Gymnin inhibits HIV-1 reverse transcriptase with an IC50 of 200 μM and the proliferation of tumor cells. Gymnin has a weak mitogenic activity toward murine splenocytes. Gymnin can be used for plant disease treatments research[1][2].
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Gymnin | Gymnin is a defensin-like antifungal peptide. Gymnin has significant antifungal activities against phytopathogenic and mycotoxigenic fungi. Gymnin inhibits HIV-1 reverse transcriptase with an IC50 of 200 μM and the proliferation of tumor cells. Gymnin has a weak mitogenic activity toward murine splenocytes. Gymnin can be used for plant disease treatments research. | |||||||||||||||||||||
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References
- [1]. Leannec-Rialland V, et al. Use of Defensins to Develop Eco-Friendly Alternatives to Synthetic Fungicides to Control Phytopathogenic Fungi and Their Mycotoxins. J Fungi (Basel). 2022 Feb 25;8(3):229. [Content Brief]
- [2]. Wong JH, et al. Gymnin, a potent defensin-like antifungal peptide from the Yunnan bean (Gymnocladus chinensis Baill). Peptides. 2003 Jul;24(7):963-8. [Content Brief]
