1428341-65-4
Chemical Structure
LG308
- CAS No.: 1428341-65-4
- Formula:C19H17FN2O
- Molecular Weight:308.35
IUPAC Name: 1-(8-fluoro-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2-phenylethan-1-one
InChIKey: CGQLRSOQDATUAX-UHFFFAOYSA-N
SMILES: FC1=CC=CC2=C1NC3=C2CCN(C(CC4=CC=CC=C4)=O)C3
Biological Activity: LG308 is a novel synthetic compound with antimicrotubule activity. LG308 induces mitotic phase arrest and inhibits G2/M progression significantly which is associated with the upregulation of cyclin B1 and mitotic marker MPM-2 and the dephosphorylation of cdc2. LG308 also induces apoptosis and cell death. LG308 significantly suppresses tumor growth. LG308 with antimitotic activity has the potential for the research of prostate cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
LG308 | LG308 is a novel synthetic compound with antimicrotubule activity. LG308 induces mitotic phase arrest and inhibits G2/M progression significantly which is associated with the upregulation of cyclin B1 and mitotic marker MPM-2 and the dephosphorylation of cdc2. LG308 also induces apoptosis and cell death. LG308 significantly suppresses tumor growth. LG308 with antimitotic activity has the potential for the research of prostate cancer. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
