142986-44-5
Chemical Structure
Starburst 1st generation (13.93% w/w in water)
Synonym(s): PAMAM G1.0
- CAS No.: 142986-44-5
- Formula:C62H128N26O12
- Molecular Weight:1429.85
InChIKey: QVWIZHOFYGKROL-UHFFFAOYSA-N
SMILES: O=C(CCN(CCC(NCCN)=O)CCNC(CCN(CCN(CCC(NCCN(CCC(NCCN)=O)CCC(NCCN)=O)=O)CCC(NCCN(CCC(NCCN)=O)CCC(NCCN)=O)=O)CCC(NCCN(CCC(NCCN)=O)CCC(NCCN)=O)=O)=O)NCCN
Biological Activity: Starburst 1st Generation (PAMAM G1.0) is a Polyamidoamine (HY-164657; PAMAM) dendrimer with amine termini that has been used as a drug delivery system in vitro. Starburst 1st Generation conjugated to di-n-dodecylamine and encapsulating 5-Fluorouracil (HY-90006) increase the solubility of 5-Fluorouracil and are cytotoxic to AGS gastric adenocarcinoma cells[1].
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Starburst 1st generation (13.93% w/w in water) | Starburst 1st Generation (PAMAM G1.0) is a Polyamidoamine (HY-164657; PAMAM) dendrimer with amine termini that has been used as a drug delivery system in vitro. Starburst 1st Generation conjugated to di-n-dodecylamine and encapsulating 5-Fluorouracil (HY-90006) increase the solubility of 5-Fluorouracil and are cytotoxic to AGS gastric adenocarcinoma cells. | |||||||||||||||||||||
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