143343-83-3
143343-83-3
Chemical Structure
Toborinone
- CAS No.: 143343-83-3
- Formula:C21H24N2O5
- Molecular Weight:384.43
InChIKey: BYKYPZBCMBEEGU-UHFFFAOYSA-N
SMILES: COC1=C(C=CC(CNCC(COC2=CC=C3C(C=CC(N3)=O)=C2)O)=C1)OC
Biological Activity: Toborinone is an inotropic agent. Toborinone increases cAMP and intracellular calcium levels through inhibiting PDE. Toborinone inhibits thrombin-induced platelet aggregation with an IC50 of 9.7 μM[1][2].
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Toborinone | Toborinone is an inotropic agent. Toborinone increases cAMP and intracellular calcium levels through inhibiting PDE. Toborinone inhibits thrombin-induced platelet aggregation with an IC50 of 9.7 μM. | |||||||||||||||||||||
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References
- [1]. MacGowan G. A. (2000). Clinical overview of the novel inotropic agent toborinone. Expert opinion on investigational drugs, 9(5), 1109-1117. [Content Brief]
- [2]. Kageyama, K., et al., (2004). Toborinone and olprinone, phosphodiesterase III inhibitors, inhibit human platelet aggregation due to the inhibition of both calcium release from intracellular stores and calcium entry. Journal of anesthesia, 18(2), 107-112. [Content Brief]
Keywords
