143984-56-9
Chemical Structure
CD2019
- CAS No.: 143984-56-9
- Formula:C25H26O3
- Molecular Weight:374.47
InChIKey: SWIWERVMTLKNLQ-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=CC=C(C3=CC(C4(CCCCC4)C)=C(OC)C=C3)C=C2C=C1)O
Biological Activity: CD2019 is a selective retinoic acid receptor β (RARβ) agonist, with a Kd value of 26 nM for RARβ and an AC50 value of 3.8 nM for human RARβ. CD2019 regulates downstream biological effects via the PI3K signaling pathway. CD2019 suppresses squamous metaplasia, inhibits squamous differentiation markers, maintains pseudostratified epithelial structure, induces neurite and axon growth, and promotes functional recovery; it exhibits cytotoxicity at higher concentrations and reduces endogenous retinol levels. CD2019 can be used in studies related to squamous metaplasia, spinal cord injury and embryonic malformations[1][2][3][4].
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CD2019 | CD2019 is a selective retinoic acid receptor β (RARβ) agonist, with a Kd value of 26 nM for RARβ and an AC50 value of 3.8 nM for human RARβ. CD2019 regulates downstream biological effects via the PI3K signaling pathway. CD2019 suppresses squamous metaplasia, inhibits squamous differentiation markers, maintains pseudostratified epithelial structure, induces neurite and axon growth, and promotes functional recovery; it exhibits cytotoxicity at higher concentrations and reduces endogenous retinol levels. CD2019 can be used in studies related to squamous metaplasia, spinal cord injury and embryonic malformations. | |||||||||||||||||||||
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- [1]. Boisvieux-Ulrich E, et al. Differential effects of several retinoid receptor-selective ligands on squamous differentiation and apoptosis in airway epithelial cells. Cell and tissue research. 2000 Apr;300(1):67-81. [Content Brief]
- [2]. Agudo M, et al. A retinoic acid receptor beta agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord. Neurobiology of disease. 2010 Jan;37(1):147-55. [Content Brief]
- [3]. Elmazar MMA, et al. Pattern of retinoid-induced teratogenic effects: Possible relationship with relative selectivity for nuclear retinoid receptors RARα, RARβ, and RARγ. Teratology. 1996;53:158-167.
- [4]. Arafa HM, et al. Selective agonists of retinoic acid receptors: comparative toxicokinetics and embryonic exposure. Archives of toxicology. 2000 Jan;73(10-11):547-56. [Content Brief]
Keywords
