14437-41-3
Chemical Structure
Clioxanide
Synonym(s): NSC 233846; SYD 230; Tremerad
- CAS No.: 14437-41-3
- Formula:C15H10ClI2NO3
- Molecular Weight:541.51
IUPAC Name: 2-((4-chlorophenyl)carbamoyl)-4,6-diiodophenyl acetate
InChIKey: ICKMASVVMCGZLR-UHFFFAOYSA-N
SMILES: CC(OC1=C(I)C=C(I)C=C1C(NC2=CC=C(Cl)C=C2)=O)=O
Biological Activity: Clioxanide is a potential anti-liver fluke (Fasciola hepatica) agent. The results showed that Clioxanide showed no efficacy against 4-week-old or 19-week-old flukes at doses of 135 mg/kg or 200 mg/kg. In contrast, hexachloroethane was very effective against older flukes, reaching 100% efficacy at lower doses. The study pointed out that laboratory mice may not be suitable for screening potential compounds against liver fluke infections in ruminants such as cattle and sheep. In addition, no obvious toxic reactions were observed in mice with Clioxanide[1].
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Clioxanide | Clioxanide is a potential anti-liver fluke (Fasciola hepatica) agent. The results showed that Clioxanide showed no efficacy against 4-week-old or 19-week-old flukes at doses of 135 mg/kg or 200 mg/kg. In contrast, hexachloroethane was very effective against older flukes, reaching 100% efficacy at lower doses. The study pointed out that laboratory mice may not be suitable for screening potential compounds against liver fluke infections in ruminants such as cattle and sheep. In addition, no obvious toxic reactions were observed in mice with Clioxanide. | |||||||||||||||||||||
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Keywords
