144576-50-1
Chemical Structure
MS-322
- CAS 番号: 144576-50-1
- Formula:C18H23ClN2O2
- Molecular Weight:334.84
IUPAC Name: (R)-1-(3-phenylisoxazol-5-yl)-2-(pyrrolidin-1-ylmethyl)butan-1-one hydrochloride
InChIKey: DGJPRBXSVZULQO-PFEQFJNWSA-N
SMILES: CC[C@H](CN1CCCC1)C(C2=CC(C3=CC=CC=C3)=NO2)=O.Cl
Biological Activity: MS-322 is an orally active centrally acting muscle relaxant. MS-322 can dose-dependently inhibit spinal reflex potentials, reduce neuronal excitability and muscle afferent discharges, and so on in rats. In addition, MS-322 has relatively weak inhibitory effects on other central nervous system pathways and no effect on the neuromuscular junction[1][2].
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MS-322 | MS-322 is an orally active centrally acting muscle relaxant. MS-322 can dose-dependently inhibit spinal reflex potentials, reduce neuronal excitability and muscle afferent discharges, and so on in rats. In addition, MS-322 has relatively weak inhibitory effects on other central nervous system pathways and no effect on the neuromuscular junction. | |||||||||||||||||||||
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- [1]. Otsu T, et al. Muscle relaxant action of MS-322, a new centrally acting muscle relaxant, in rats. Gen Pharmacol. 1998 Mar;30(3):393-8. [Content Brief]
- [2]. Otsu T, et al. Pharmacological properties of the new centrally acting muscle relaxant (R)-(+)-3-phenyl-5-[2-(1-pyrrolidinylmethyl) butyryl] isoxazole hydrochloride. Arzneimittel-forschung, 1997, 47(6): 706-709.
Keywords
