144860-68-4
Chemical Structure
Reveromycin B
- CAS No.: 144860-68-4
- Formula:C36H52O11
- Molecular Weight:660.79
IUPAC Name: (2E,4S,5S,6E,8E)-10-((2R,5S,7R,8S)-2-butyl-2-((S,2E,4E)-5-carboxy-1-((3-carboxypropanoyl)oxy)-4-methylpenta-2,4-dien-1-yl)-8-methyl-1,6-dioxaspiro[4.5]decan-7-yl)-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid
InChIKey: XVFQIVPMOPJEIO-OXVOKJAASA-N
SMILES: CC(/C=C/[C@H](O)[C@@H](C)/C=C/C(O)=O)=C\C[C@H]1O[C@]2(CC[C@@H]1C)CC[C@@](CCCC)(O2)[C@@H](OC(CCC(O)=O)=O)/C=C/C(C)=C/C(O)=O
Biological Activity: Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC50=6 μg/mL) and exhibits pH-dependent antifungal activity against C. albicans (MICs=15.6 and >500 μg/mL at pH 3.0 and 7.4, respectively). Unlike reveromycin A and reveromycin C, reveromycin B does not inhibit proliferation of KB and K562 cells.
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Reveromycin B | Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC50=6 μg/mL) and exhibits pH-dependent antifungal activity against C. albicans (MICs=15.6 and >500 μg/mL at pH 3.0 and 7.4, respectively). Unlike reveromycin A and reveromycin C, reveromycin B does not inhibit proliferation of KB and K562 cells. | |||||||||||||||||||||
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